Risk Factors for Tigecycline-Associated Hypofibrinogenemia

A Lesser Known Side Effect of Tigecycline: Hypofibrinogenemia

Fibrinogen is a soluble protein that is produced in hepatocytes. It participates in blood coagulation and is considered as an acute phase protein with a half-life of 3 to 4 days [1,2]. Fibrinogen values range from 200 to 400 mg/dL [1,3]. While hyperfibrinogenemia is correlated with systemic inflammation and malignancy, hypofibrinogenemia can be observed in chronic inherited diseases, acquired h...

Tigecycline-associated hypofibrinogenemia: A case report and review of the literature

Tigecycline, a glycylcycline-derived antibacterial that has been approved for the treatment of various infections, is widely used for multi-drug resistant bacteria. Coagulopathy is an uncommon side effect during tigecycline treatment and is easily overlooked when it occurs. We reported the effect of tigecycline (50 mg every twelve hours) treatment in an 87-year-old man, with Gram negative bacil...

P-71: Risk Factors Associated with Womens

Pnm-4: Risk Factors Associated with Infertility

Background Infertility is the inability to conceive children after one year of unprotected intercourse. The estimated prevalence of infertility in Canada is 11.5-15.7%. Fertility problems affect approximately one in seven couples in the United Kingdom (UK). Infertility occurs in conditions in which the pregnancies end with recurrent miscarriages (ASR) or birth of a child with multiple congenita...

A case report of patient with severe acute cholangitis with tigecycline treatment causing coagulopathy and hypofibrinogenemia

RATIONALE Tigecycline is the first member of the glycylcycline family. There are rarely reports of tigecycline causing coagulopathy and hypofibrinogenemia until now. We report a case on tigecycline-associated coagulopathy and hypofibrinogenemia and discuss the characteristics of the adverse reaction. PATIENT CONCERNS A 47-year-old male patient with severe acute cholangitis who developed sepsi...